Researching Remedies in Intellectual Property Actions Involving Computer Technology: A Research Guide

The purpose of this research guide is not to answer the question What remedies are available to an owner of computer related technology whose rights have been infringed? but to provide a methodology by which a legal practitioner can find the answer to this question. This guide sets forth materials and methods of research that can be used for an inquiry that is broad in scope, such as researching which legal scheme\u27s remedial component best suits a client\u27s technology, but that are also capable of being used for a narrow or limited inquiry, such as looking for specific remedies available in litigation to enforce a client\u27s rights. The guide points to many useful materials that practitioners in the field of intellectual property will find very helpful. The article will prove to be an invaluable resource to those doing research in the area of intellectual property for the first time, and to those law office librarians who are looking to gather intellectual property resources for attorneys conducting such research

Researching Remedies in Intellectual Property Actions Involving Computer Technology: A Research Guide

The purpose of this research guide is not to answer the question What remedies are available to an owner of computer related technology whose rights have been infringed? but to provide a methodology by which a legal practitioner can find the answer to this question. This guide sets forth materials and methods of research that can be used for an inquiry that is broad in scope, such as researching which legal scheme\u27s remedial component best suits a client\u27s technology, but that are also capable of being used for a narrow or limited inquiry, such as looking for specific remedies available in litigation to enforce a client\u27s rights. The guide points to many useful materials that practitioners in the field of intellectual property will find very helpful. The article will prove to be an invaluable resource to those doing research in the area of intellectual property for the first time, and to those law office librarians who are looking to gather intellectual property resources for attorneys conducting such research

Augmented GNSS Differential Corrections Minimum Mean Square Error Estimation Sensitivity to Spatial Correlation Modeling Errors

Railway signaling is a safety system that has evolved over the last couple of centuries towards autonomous functionality. Recently, great effort is being devoted inthis field, towards the use and exploitation of Global Navigation Satellite System (GNSS)signals and GNSS augmentation systems in view of lower railway track equipments andmaintenance costs, that is a priority to sustain the investments for modernizing the local andregional lines most of which lack automatic train protection systems and are still manuallyoperated. The objective of this paper is to assess the sensitivity of the Linear Minimum MeanSquare Error (LMMSE) algorithm to modeling errors in the spatial correlation function thatcharacterizes true pseudorange Differential Corrections (DCs). This study is inspired bythe railway application; however, it applies to all transportation systems, including the roadsector, that need to be complemented by an augmentation system in order to deliver accurateand reliable positioning with integrity specifications. A vector of noisy pseudorange DCmeasurements are simulated, assuming a Gauss-Markov model with a decay rate parameterinversely proportional to the correlation distance that exists between two points of a certainenvironment. The LMMSE algorithm is applied on this vector to estimate the true DC, andthe estimation error is compared to the noise added during simulation. The results show thatfor large enough correlation distance to Reference Stations (RSs) distance separation ratiovalues, the LMMSE brings considerable advantage in terms of estimation error accuracy and precision. Conversely, the LMMSE algorithm may deteriorate the quality of the DCmeasurements whenever the ratio falls below a certain threshold

A new peer-to-peer aided acquisition approach exploiting C/N0 aiding

The aim of this paper is to present an acquisition strategy for Global Navigation Satellite System (GNSS) signals exploiting aiding information provided by GNSS receivers in a Peer-to-Peer (P2P) positioning system. This work sheds light on the benefits of sharing information regarding the received satellite signal power: the Carrier-to-Noise density ratio (C/N0) estimated by aiding peers relatively close to each other, is used to optimize signal acquisition capability in terms of detection performance as well as Mean Acquisition Time (MAT). The proposed approach has been validated and assessed using real data collected with an experimental setup in light indoor conditions and by means of simulations. The performance obtained has also been compared with an Assisted-GNSS (A-GNSS) like acquisition strategy, showing the benefits of the availability of C/N0 aiding information in terms of MAT. ©2010 IEEE

To soothe or remove? Affect, revanchism and the weaponized use of classical music

Over the past 30 years, in the United Kingdom, Canada and the United States, classical music has come to function as a sonic weapon. It is used a means of dispelling and deterring ‘loiterers’ by making particular public and privately owned public spaces – such as shopping malls, bus stations, shop fronts and car parks – undesirable to occupy. In this article, I present weaponized classical music as a ‘revanchist’, audio-affective deterrent. Drawing upon Neil Smith’s description of the revanchist city, I examine how weaponized classical music works to affectively police neoliberal ‘public’ space. While credited with the capacity to ‘soothe away’ deviant behaviour through its calming influence, weaponized classical music ultimately aims to ‘remove’ the figure of the threatening and menacing ‘loiterer’ insofar as it is heard as repellent. Although affect has often been understood in contradistinction to social determinisms, weaponized classical music exemplifies the capacity of musical affects to function as a technology of social reproduction

Real-world outcomes of sipuleucel-T treatment in PROCEED, a prospective registry of men with metastatic castration-resistant prostate cancer.

BackgroundThe large registry, PROVENGE Registry for the Observation, Collection, and Evaluation of Experience Data (PROCEED)(NCT01306890), evaluated sipuleucel-T immunotherapy for asymptomatic/minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC).MethodsPROCEED enrolled patients with mCRPC receiving 3 biweekly sipuleucel-T infusions. Assessments included overall survival (OS), serious adverse events (SAEs), cerebrovascular events (CVEs), and anticancer interventions (ACIs). Follow-up was for ≥3 years or until death or study withdrawal.ResultsIn 2011-2017, 1976 patients were followed for 46.6 months (median). The median age was 72 years, and the baseline median prostate-specific antigen level was 15.0 ng/mL; 86.7% were white, and 11.6% were African American. Among the patients, 1902 had 1 or more sipuleucel-T infusions. The median OS was 30.7 months (95% confidence interval [CI], 28.6-32.2 months). Known prognostic factors were independently associated with OS in a multivariable analysis. Among the 1255 patients who died, 964 (76.8%) died of prostate cancer (PC) progression. The median time from the first infusion to PC death was 42.7 months (95% CI, 39.4-46.2 months). The incidence of sipuleucel-T-related SAEs was 3.9%. The incidence of CVEs was 2.8%, and the rate per 100 person-years was 1.2 (95% CI, 0.9-1.6). The CVE incidence among 11,972 patients with mCRPC from the Surveillance, Epidemiology, and End Results-Medicare database was 2.8%; the rate per 100 person-years was 1.5 (95% CI, 1.4-1.7). One or more ACIs (abiraterone, enzalutamide, docetaxel, cabazitaxel, or radium 223) were received by 77.1% of the patients after sipuleucel-T; 32.5% and 17.4% of the patients experienced 1- and 2-year treatment-free intervals, respectively.ConclusionsPROCEED provides contemporary survival data for sipuleucel-T-treated men in a real-world setting of new life-prolonging agents, which will be useful in discussing treatment options with patients and in powering future trials with sipuleucel-T. The safety and tolerability of sipuleucel-T in PROCEED were consistent with previous findings

Beneath a Steel Sky: A Musical Characterisation of Class Structure

This article proposes Revolution Software’s Beneath a Steel Sky (1994) as a starting point for the analysis of the relationship between music and social class in video games. While other issues of representation have been studied extensively within game studies (gender representation in particular), the representation of class remains an underexplored area. Furthermore, the relationship between video game music and socio-cultural aspects of video game studies is also rarely examined beyond issues of race, ethnicity, and cultural appropriation. This article draws connections between these two underexplored areas and analyses the musical characterisation of class in the 1994 cyberpunk adventure game, which takes places largely in a literally stratified metropolis where the three levels of the city act as representations of the three social classes. Here, music plays an important role in terms of environmental storytelling, both as semiotic shorthand, and as a reflection of the affordances available to the inhabitants of the city

Sustained seizure freedom with adjunctive brivaracetam in patients with focal onset seizures

The maintenance of seizure control over time is a clinical priority in patients with epilepsy. The aim of this study was to assess the sustained seizure frequency reduction with adjunctive brivaracetam (BRV) in real-world practice. Patients with focal epilepsy prescribed add-on BRV were identified. Study outcomes included sustained seizure freedom and sustained seizure response, defined as a 100% and a ≥50% reduction in baseline seizure frequency that continued without interruption and without BRV withdrawal through the 12-month follow-up. Nine hundred ninety-four patients with a median age of 45 (interquartile range = 32–56) years were included. During the 1-year study period, sustained seizure freedom was achieved by 142 (14.3%) patients, of whom 72 (50.7%) were seizure-free from Day 1 of BRV treatment. Sustained seizure freedom was maintained for ≥6, ≥9, and 12 months by 14.3%, 11.9%, and 7.2% of patients from the study cohort. Sustained seizure response was reached by 383 (38.5%) patients; 236 of 383 (61.6%) achieved sustained ≥50% reduction in seizure frequency by Day 1, 94 of 383 (24.5%) by Month 4, and 53 of 383 (13.8%) by Month 7 up to Month 12. Adjunctive BRV was associated with sustained seizure frequency reduction from the first day of treatment in a subset of patients with uncontrolled focal epilepsy

Adjunctive Brivaracetam in Focal Epilepsy: Real-World Evidence from the BRIVAracetam add-on First Italian netwoRk STudy (BRIVAFIRST)

Background: In randomized controlled trials, add-on brivaracetam (BRV) reduced seizure frequency in patients with drug-resistant focal epilepsy. Studies performed in a naturalistic setting are a useful complement to characterize the drug profile. Objective: This multicentre study assessed the effectiveness and tolerability of adjunctive BRV in a large population of patients with focal epilepsy in the context of real-world clinical practice. Methods: The BRIVAFIRST (BRIVAracetam add-on First Italian netwoRk STudy) was a retrospective, multicentre study including adult patients prescribed adjunctive BRV. Patients with focal epilepsy and 12-month follow-up were considered. Main outcomes included the rates of seizure‐freedom, seizure response (≥ 50% reduction in baseline seizure frequency), and treatment discontinuation. The incidence of adverse events (AEs) was also considered. Analyses by levetiracetam (LEV) status and concomitant use of strong enzyme-inducing antiseizure medications (EiASMs) and sodium channel blockers (SCBs) were performed. Results: A total of 1029 patients with a median age of 45 years (33–56) was included. At 12 months, 169 (16.4%) patients were seizure-free and 383 (37.2%) were seizure responders. The rate of seizure freedom was 22.3% in LEV-naive patients, 7.1% in patients with prior LEV use and discontinuation due to insufficient efficacy, and 31.2% in patients with prior LEV use and discontinuation due to AEs (p < 0.001); the corresponding values for ≥ 50% seizure frequency reduction were 47.9%, 29.7%, and 42.8% (p < 0.001). There were no statistically significant differences in seizure freedom and seizure response rates by use of strong EiASMs. The rates of seizure freedom (20.0% vs. 16.6%; p = 0.341) and seizure response (39.7% vs. 26.9%; p = 0.006) were higher in patients receiving SCBs than those not receiving SCBs; 265 (25.8%) patients discontinued BRV. AEs were reported by 30.1% of patients, and were less common in patients treated with BRV and concomitant SCBs than those not treated with SCBs (28.9% vs. 39.8%; p = 0.017). Conclusion: The BRIVAFIRST provided real-world evidence on the effectiveness of BRV in patients with focal epilepsy irrespective of LEV history and concomitant ASMs, and suggested favourable therapeutic combinations